本研究旨在评估联动成像技术（LCI）在提高浅表非壶腹部十二指肠上皮肿瘤（SNADETs）可见性方面的功效，我们前瞻性地评估了44名连续诊断为SNADET的患者。三名实习和三名专家内镜医师评估了SNADET的白光成像（WLI）、LCI和BLI-bright的可见性分数，范围从1（未经反复仔细检查无法检测到）到4（出色的可见性）。此外，使用CIELAB色彩空间系统评估L* a* b*颜色值和色差（ΔE*）。对于SNADET，LCI的可见性得分（3.53 ± 0.59）显著高于WLI和BLI-bright（分别为2.66 ± 0.79和3.41 ± 0.64）。LCI模式下SNADETs与相邻正常十二指肠黏膜之间的色差（ΔE*）（19.09 ± 8.33）显著高于白光和BLI-bright模式（分别为8.67 ± 4.81和12.92 ± 7.95）。此外，无论是否存在乳白色黏膜（MWM），LCI模式下SNADETs的可见性得分和色差均显著高于白光和BLI-bright模式。LCI具有潜在的好处，它被认为是一种有前途的临床模式，无论是否存在MWM，它都可以提高SNADET的可见性。

Abstract: The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of white light imaging (WLI), LCI, and blue laser imaging-bright (BLI-b) for SNADETs, which ranged from 1 (not detectable without repeated cautious examination) to 4 (excellent visibility). In addition, the L* a* b* color values and color differences (ΔE*) were evaluated using the CIELAB color space system. For SNADETs, the visibility scores of LCI (3.53 ± 0.59) were significantly higher than those of WLI and BLI-b (2.66 ± 0.79 and 3.41 ± 0.64, respectively). The color differences (ΔE*) between SNADETs and the adjacent normal duodenal mucosa in LCI mode (19.09 ± 8.33) were significantly higher than those in WLI and BLI-b modes (8.67 ± 4.81 and 12.92 ± 7.95, respectively). In addition, the visibility score of SNADETs and the color differences in LCI mode were significantly higher than those in WLI and BLI-b modes regardless of the presence of milk white mucosa (MWM). LCI has potential benefits, and it is considered a promising clinical modality that can increase the visibility of SNADETs regardless of the presence of MWM.