王晔：LCI的临床应用进展

*以下内容中所有出现的LCI指联动成像技术 (LCI: Linked Color lmaging); BLI指蓝光成像技术 (BLI: Blue Light lmaging)

王晔主任从以下几个方面进行讲解：

- 内镜成像技术的发展史

- BLI和LCI的技术原理

- LCI对食管，胃和结肠的临床应用优势

以下内容为部分摘要，完整内容敬请点击视频观看！

LCI在食管的临床应用：IIb型的早期食管癌往往很难被发现，而LCI突出了色彩的变化，更容易诊断

有研究文献证明：

1. LCI更容易发现表浅型食管鳞癌¹；

2.能够区分食管鳞癌与上皮内瘤变²；

3.判断食管鳞状细胞癌侵犯深度³；

LCI在胃的临床应用：胃镜除了发现早癌，还可以判断患者胃癌的风险，特别是幽门螺杆菌感染状态。根据京都胃炎分类，不同内镜下的表现，我们可以判断患者处于哪个状态（HP未感染/HP感染/HP除菌后）

有研究文献证明：

1. LCI下对于幽门螺旋杆菌感染诊断率高于白光，特别是除菌后状态的诊断⁴

2. LCI下对于早期胃癌病灶范围判断的准确率明显优于白光⁵

3. 在日常胃镜筛查下，超细内镜结合LCI模式判断早癌的阳性率优于白光内镜⁶

4. LCI模式下，诊断除菌后的胃癌漏诊率明显低于白光内镜⁷

LCI在结肠的临床应用：可预测结肠息肉的病理类型

有研究文献证明：

1. 和白光内镜相比，LCI预测病理类型敏感性和特异性更高，不同观察者的一致性更高。增生性息肉颜色更偏白（接近于背景黏膜），腺瘤黏膜更红，LCI下色彩差异更明显⁸

2. LCI下区分腺瘤、无蒂锯齿状息肉、增生性息肉和非增生性息肉准确度更高⁹

3. LCI能够提高结直肠息肉的检出率，特别对于＜10mm的微小息肉差异性更明显¹⁰

4. LCI能够提高SSA/P检出率，特别是平坦型病变，无蒂锯齿状病变¹¹

5. LCI可判断溃疡性结肠炎的活动性和预测复发风险¹²

6. LCI 判断UC相关的结直肠癌的检出率更高¹³

文献出处

[1] Nakamura, Koki, et al. "Usefulness of linked color imaging in the early detection of superficial esophageal squamous cell carcinomas." Esophagus 18 (2021): 118-124.

[2] Tsunoda, Masato, et al. "New diagnostic approach for esophageal squamous cell neoplasms using linked color imaging and blue laser imaging combined with iodine staining." Clinical Endoscopy 52.5 (2019): 497-501.

[3] Kobayashi, Kenichi, et al. "Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma." Digestive Endoscopy 32.1 (2020): 65-73.

[4] Dohi, Osamu, et al. "Linked color imaging improves endoscopic diagnosis of active Helicobacter pylori infection." Endoscopy international open 4.07 (2016): E800-E805.

[5] Fockens, Kiki, et al. "Linked color imaging improves identification of early gastric cancer lesions by expert and non-expert endoscopists." Surgical Endoscopy 36.11 (2022): 8316-8325.

[6] Khurelbaatar, Tsevelnorov, et al. "Improved detection of early gastric cancer with linked color imaging using an ultrathin endoscope: a video-based analysis." Endoscopy International Open 10.05 (2022): E644-E652.

[7] Kitagawa, Yoshiyasu, et al. "Comparison of endoscopic visibility and miss rate for early gastric cancers after Helicobacter pylori eradication with white‐light imaging versus linked color imaging." Digestive Endoscopy 32.5 (2020): 769-777.

[8] Min, Min, et al. "Development and validation of the linked color imaging classification for endoscopic prediction of colorectal polyp histology." Journal of Digestive Diseases 23.5-6 (2022): 310-317.

[9] Houwen, Britt BSL, et al. "Real-time diagnostic accuracy of blue light imaging, linked color imaging and white-light endoscopy for colorectal polyp characterization." Endoscopy International Open 10.01 (2022): E9-E18.

[10] Wang, Jun, et al. "The Effect of Linked Color Imaging for Adenoma Detection. A Meta-analysis of Randomized Controlled Studies." Journal of Gastrointestinal & Liver Diseases 31.1 (2022).

[11] Li, Jun, et al. "Colorectal sessile serrated lesion detection using linked color imaging: A multicenter, parallel randomized controlled trial." Clinical Gastroenterology and Hepatology 21.2 (2023): 328-336.

[12] Matsumoto, Kenta, et al. "Clinical usefulness of linked color imaging for evaluation of endoscopic activity and prediction of relapse in ulcerative colitis." International Journal of Colorectal Disease 36 (2021): 1053-1061. [13] Kanmura, Shuji, et al. "A case of screening colonoscopy using linked-color imaging to detect ulcerative colitis–associated colorectal cancer." Digestive and Liver Disease 51.7 (2019): 1061.

讲课出处：中国医药卫生事业发展基金会消化专家委员会第二届年会